I tried it on my Lenovo All In One desktop system, with 4GB of RAM and an i3 processor. To be honest, I really didn't notice any change in speed. I had a 32GB USB memory stick sitting around so I gave it a try in my USB 3.0 port and configured it as instructed. It really didn't make any difference when I was doing some resource heavy stuff in Photoshop or playing a game or rendering some video. I've read elsewhere that if you have over 2GB of memory, it's really not going to help anything.
I even had some other program running in conjunction that was supposed to routinely free up any memory that programs were holding on to, and honestly it felt like my computer was running more slowly if anything. It would routinely seize up when it was trying to flush some of the memory.